Cooperative base pair melting by helicase and polymerase positioned one nucleotide from each other
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چکیده
منابع مشابه
Cooperative base pair melting by helicase and polymerase positioned one nucleotide from each other
Leading strand DNA synthesis requires functional coupling between replicative helicase and DNA polymerase (DNAP) enzymes, but the structural and mechanistic basis of coupling is poorly understood. This study defines the precise positions of T7 helicase and T7 DNAP at the replication fork junction with single-base resolution to create a structural model that explains the mutual stimulation of ac...
متن کاملCooperative base pair melting by helicase and polymerase positioned one 1 nucleotide from each other 2
Cooperative base pair melting by helicase and polymerase positioned one 1 nucleotide from each other 2 Divya Nandakumar, Manjula Pandey and Smita S. Patel* 3 Department of Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, 4 675 Hoes Lane west, Piscataway, NJ 08854, USA 5 *Corresponding author. Tel.: 732-235-3372; FAX: 732-235-4783; E-mail: [email protected] 6 7 R...
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ژورنال
عنوان ژورنال: eLife
سال: 2015
ISSN: 2050-084X
DOI: 10.7554/elife.06562